recommended VADs according to previous guideline and reviews
| Symptoms | UIP 2018 (1) | Cochrane 2020 (8) | Umbrella review 2022 (9) | Commercial durgs in Korea |
|---|---|---|---|---|
| Edema | Cyclo3, HCSE | Diosmin, Rutosides | 베니톨, 플라벤, 디오스민, 치센, 엘라스에이 | |
| Ankle circumference | Cyclo3, HCSE | Diosmin | MPFF, Ruscus, Oxerutins | 베니톨, 플라벤, 디오스민, 치센, 뉴베인 |
| Leg volume | Cyclo3, HCSE, ca+ dobesilate | ca+dobesilate | MPFF, Ruscus, HCSE | 베니톨, 플라벤, 디오스민, 치센, 독시움 |
| Pain | MPFF, Cyclo3, Oxerutins, HCSE | Diosmin, Rutosides, ca+dobesilate | MPFF, Ruscus, HCSE | 베니톨, 플라벤, 디오스민, 치센, 뉴베인, |
| Cramps | MPFF, Oxerutins | Diosmin, Rutosides, ca+dobesilate | MPFF, Ruscus | 베니톨, 플라벤, 디오스민, 치센, 독시움 |
| Heaviness | MPFF, Cyclo3, Oxerutins, ca+dobesilate | Diosmin, Rutosides | MPFF, Ruscus | 베니톨, 플라벤, 디오스민, 치센, 뉴베인, 독시움 |
| Feeling of swelling | MPFF, Cyclo3 | ca+dobesilate | MPFF | 베니톨, 플라벤 |
| Ulcer | MPFF, Oxerutins | 베니톨, 플라벤, 뉴베인 | ||
| Functional discomfort | MPFF | MPFF | 베니톨, 플라벤 | |
| Skin change | MPFF | Diosmin | MPFF | 베니톨, 플라벤, 디오스민 |
| Restless leg | ca+dobesilate | 독시움 | ||
| Pruritis/Itching | Oxerutins, HCSE | Rutosides | HCSE | 뉴베인 |
| Paraesthesia | Cyclo3 | Rutosides | MPFF | 베니톨, 플라벤 |
| Leg fatique | Cyclo3 | |||
| QoL | MPFF | MPFF | 베니톨, 플라벤 | |
| Burning sensation | MPFF | 베니톨, 플라벤 |
Cyclo 3 fort®, Ruscus extract+hesperidin methyl chalcone (HMC)+vitamin C UIP, L’Union Internationale de Phlébologie. MPFF: micronized purified flavonoid fraction, HCSE: horse chestnut seed extract.